Collagen provides integrity to the extracellular matrix, and plays a critical role in maintaining connective tissue, joint and bone health. Joint structures of the musculoskeletal system provide normal joint integrity, stability and joint mechanics necessary for maintaining activities of daily living and athletic performance. When the joint structures, cartilage and subcondral bone, are exposed to inflammation, oxidative stress, injury and mechanical stress, osteoarthritis can develop and compromise joint health.
The early onset of degenerative joint changes can begin well before signs and symptoms are experienced. These changes can be initiated by exposure to youth athletic injury, exercise in excess, and sedentary lifestyle, and perpetuated by poor nutritional habits and excess body weight.
Collagen and Polyphenol Nutraceuticals provide joint health support without the dangers of non-steroidal anti-inflammatory drugs(NSAID's).
The joint articular structures, specifically the cartilage of the articular surfaces of weight bearing joints(spine, hips, knees and ankles) are susceptible to a cascading degenerative decline. There are increased risk of joint degeneration in the population:
- Overweight & Obesity
- Occupational stressors
- Athletic and Exercise Injury
- Genetic Predisposition
It has been shown the former elite soccer athletes are at a high risk for knee and ankle osteoarthritis in comparison with the general population.(2012).
Soccer related injury to the Anterior Cruciate Ligament (ACL) in female athletes occur 3-5 times more frequently than males.
Joint injury, such as Anterior Cruciate Ligament (ACL) tear and meniscal, or ligamentous sprain, may initiate the degenerative process associated with an athletic injury, it may take years for pain and the associated limitation of mobility and functional decline to be apparent.
With ACL injury, inflammatory mediators are elevated. This induces a chondral(articular cartilage) destructive environment through a series of catabolic events.
A knee with a prior ACL injury is 4 times as likely to have knee OA compared to a non ACL injury on the opposite knee(see study),
An environment of elevated joint swelling, synovitis and increased inflammatory biomarkers perpetuate the degenerative process by degrading the collagen that comprises articular surfaces.
These changes can be induced by external physical stress(excess loading), inflammation, oxidative stress, diabetes and congenital joint deformities.
Collagen and Polyphenol Nutraceuticals Provide Joint Health
Laboratory and in vivo studies demonstrate the chondroprotective influence of collagen and the phenolic compound Hydroxytyrosol. The supplements act against inflammatory biomarkers, have strong anti-oxidant capacity and provide the amino acid framework necessary for cartilage metabolism and joint health.
Collagen Type II - TendoGuard™
Type II Collagen is degraded with continued infiltration of inflammatory cytokines and activation of catabolic(breaking-down) proteinases.
The amino acid profile of collagen hydrolysate supplies glycine and proline essential for the stabilizing and regenerative processes of cartilage metabolism.
TendoGuard™ is comprised of Collagen Type I, II, V. X isolated from 100% Avian Eggshell Membrane and Sternum Cartilage.
The Hydrolyzed Eggshell Membrane contains very powerful compounds including: a complex of glycosaminoglycans such as glucosamine, chondroitin and hyaluronic acid, elastin, collagen, desmosine, isodesmosine and transforming growth factor-β and other effective compounds.
Collagen Type II accounts for 90-95% of the articular cartilage collagen.
TendoGuard™ provides denatured Type II Collagen (U.S. Patent #8,344,106 B1)
Type II denatured chicken collagen processed using an exclusive water extraction technology process without a solvent (ethanol) to change the original molecules for assimilation. The ingredient is recognized as a nutrient and building block for damaged cartilage. This process maintains the integrity of its delicate molecules. The long chain of amino acids are left intact, ensuring the body’s own superior natural enzymes recognize the precise genetic code for maximum assimilation for ultimate joint health.
Collagen promotes structural recovery from injurious strains of the muscle, tendons, ligaments and cartilage.
Anti-oxidant and Anti-Inflammatory Properties of Hydroxytyrosol
Hydroxytyrosol is a major phenolic compound found in olive oil and olive leaf.
Hydroxytyrosol contributes to the health and lowered incidence of chronic disease associated to the Mediterranean Diet.
Research suggests that hydroxyytrosol has great potential as a chondroprotective nutraceutical against osteoarthritis by anti-oxidant ability, autophagy and SIRT-1 inducement.(Cetrullo, et al.)
Hydroxytyrosol reduces oxidative stress and damage, exerts pro-survival and anti-apoptotic actions and favourably influences the expression of critical OA-related genes in human chondrocytes treated with stressors promoting OA-like features. (Facchini, et al.)This same study concluded from their results that Hydroxytyrosol, protects human chondrocytes from destruction and prevents OA features.
Olea25® Hydroxytyrosol is a patented olive leaf extraction of polyphenols Hydroxytyrosol biotransformed from Oleuropein.
See Health Benefits of Olea25® Hydroxytyrosol (Slidedeck)
Hydroxytyrosol has cytoprotective, anti-inflammatory, antioxidant and cardioprotective actions that include the prevention and treatment of chronic degenerative diseases.
Natural Joint Health Solutions Olea25® Hydroxytyrosol and TendoGuard™
Early onset of degenerative joint disease result from a range of joint stress that includes:
- Youth Athletic Injury
- Sedentary Lifestyle
- Overuse Exposure to Joint Stress
- Oxidative Stress
- Chronic Inflammation
Your natural choice for Joint Health support are the polyphenol actions of Olea25® Hydroxytyrosol and the Full-Ppectrum Collagen and Hydrolyzed Eggshell Membrane action of TendoGuard™.