Olive Leaf and Oil Polyphenol Hydroxytyrosol Role in Disease Prevention

antioxidant health benefits Health benefits hydroxytyrosol olive leaf olive oil polyphenol Polyphenol disease prevention

Hydroxytyrosol(HT),a natural polyphenol from Olive Leaf (OL) and Extra Virgin Olive Oil (EVOO), is considered to be one of the most effective antioxidants. Studies indicate that consumption of HT is associated with better heart health, anti-inflammation, anti-oxidant, all of which support disease prevention.

The health benefits of the Mediterannean Diet attribute the polyphenol HT as having a primary role supporting the decreased heart disease, cancer and cognitive decline found in this region.  

Hydroxytyrosol (HT) is the only polyphenol that has been granted a European Food Safety Authority health claim.



The growing body of research supports Hydroxytyrosol use in disease prevention in the areas of cardiovascular, neurological, mitochondrial and metabolic health.

In human and animal studies hydroxytyrosol shows significant therapeutic effects on the cardiovascular system, improve the quality of life of patients with osteoporosis, and reducing markers of inflammation.

Olea25® is 25% Hydroxytyrosol extracted from olive leaf in dry basis form. This extraction is not from Olive Mill Waste or synthetic. The additional 75% Contained in the 100mg capsule of Olea25 is comprised of additional polyphenols that add to strong anti-oxidant capacity of this product.

Olea25® is the newest discovery of a powerful SUPER antioxidant with an ORAC value exceeding 68,000 µmolTE/g,which is 15 times higher than green tea and more than 3 times higher than CoQ10.- Certified Nutraceuticals(patent pending)

Olea25® Hydroxytyrosol has therapeutic benefits that make its' application suitable for health supporting nutraceutical supplementation with a healthy diet, a functional food, and extended benefits to the agricultural and cosmeceutical industry.

The Role and Mechanisms of Olive Oil Polyphenol Hydroxytyrosol in Disease Prevention 

Rodríguez-Morató J, Xicota L, Fitó M, Farré M, Dierssen M, de la Torre R. Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases. Molecules. 2015; 20(3):4655-4680. 

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Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main source of lipids in the MD, is rich in minor phenolic components, particularly hydroxytyrosol (HT). HT potent antioxidant and anti-inflammatory actions have attracted researchers’ attention and may contribute to neuroprotective effects credited to MD. In this review HT bioavailability and pharmacokinetics are presented prior to discussing health beneficial effects. In vitro and in vivo neuroprotective effects together with its multiple mechanisms of action are reviewed. Other microconstituents of olive oil are also considered due to their potential neuroprotective effects (oleocanthal, triterpenic acids). Finally, we discuss the potential role of HT as a therapeutic tool in the prevention of neurodegenerative diseases.

Key Point:

Hydroxytyrosol, a polyphenol found in EVOO and Olive Leaf, is a potent anti-inflammatory and anti-oxidant that contributes to the neuroprotective effects of the Mediterranean Diet.


Mechanisms of Action of Phenolic Compounds in Olive

Haloom Rafehi, Katherine Ververis, and Tom C. Karagiannis,Mechanisms of Action of Phenolic Compounds in Olive. Journal Of Dietary Supplements Vol. 9 , Iss. 2,2012

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Olive oil, an oil rich in monounsaturated fatty acids (MUFA's) and minor constituents including phenolic compounds, is a major component of the Mediterranean diet. The potential health benefits of the Mediterranean diet were highlighted by the seminal Seven Countries Study, and more contemporary research has identified olive oil as a major element responsible for these effects. It is emerging that the phenolic compounds are the most likely candidates accounting for the cardioprotective and cancer preventative effects of extra virgin olive oil (EVOO). In particular, the phenolic compound, hydroxytyrosol has been identified as one of the most potent antioxidants found in olive oil. This review will briefly consider historical aspects of olive oil research and the biological properties of phenolic compounds in olive oil will be discussed. The focus of the discussion will be related to the mechanisms of action of hydroxytyrosol. Studies have demonstrated that hydroxytyrosol induces apoptosis and cell cycle arrest in cancer cells. Further, research has shown that hydroxytyrosol can prevent cardiovascular disease by reducing the expression of adhesion molecules on endothelial cells and preventing the oxidation of low-density lipoprotein (LDL). The molecular mechanisms accounting for these effects are reviewed.

Key Point:

Hydroxytyrosol is a potent anti-oxidant found in EVOO and has a role in the prevention of cardiovascular disease and cancer through molecular mechanisms

Olea25® Hydroxytyrosol

Olea25® Hydroxytyrosol is a food grade natural organic olive leaf extract processed into an ideal 25% Hydroxytyrosol.
Olea25® Hydroxytyrosol is a polyphenol with strong anti-oxidant and anti-inflammatory properties that support:
  • Cellular Protection
  • Heart Health
  • Cellular Metabolism
  • Diabetes Support
  • Inflammation and Joint Health
  • Neuroprotection
  • Detoxification


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